Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci

M Esteller; A García; J M Martínez-Palones; J Xercavins; J Reventós

doi:10.1038/bjc.1997.235

Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci

Br J Cancer. 1997;75(9):1385-8. doi: 10.1038/bjc.1997.235.

Authors

M Esteller¹, A García, J M Martínez-Palones, J Xercavins, J Reventós

Affiliation

¹ Unitat de Recerca Biomedica, Centre d'Investigacions en Bioquimica i Biologia Molecular, Hospital Universitari Materno-Infantil Vall d'Hebron, Barcelona, Spain.

Abstract

A case-control study was designed to identify associations between polymorphisms at p53, cytochrome P-450 (CYP1A1) and glutathione-S-transferases and endometrial cancer susceptibility. Among all polymorphisms analysed, an insertional variant in p53 (P53PIN3) and two polymorphisms in the 3'-end and exon 7 of CYP1A1 showed significant association with enhanced endometrial cancer risk.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Alleles*
Biomarkers, Tumor
Carcinoma / etiology*
Carcinoma / genetics
Carcinoma / metabolism
Case-Control Studies
Cytochrome P-450 CYP1A1 / genetics*
Cytochrome P-450 CYP1A1 / metabolism
DNA, Neoplasm / analysis
Endometrial Neoplasms / etiology*
Endometrial Neoplasms / genetics
Endometrial Neoplasms / metabolism
Female
Genes, p53 / genetics*
Glutathione Transferase / genetics*
Glutathione Transferase / metabolism
Humans
Middle Aged
Polymorphism, Genetic

Substances

Biomarkers, Tumor
DNA, Neoplasm
Cytochrome P-450 CYP1A1
Glutathione Transferase