Abstract
The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.
MeSH terms
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Amino Acid Sequence
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Binding Sites
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Bone Morphogenetic Protein 7
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Bone Morphogenetic Proteins / chemistry
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Crystallography, X-Ray
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Dimerization
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Drosophila Proteins*
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Glial Cell Line-Derived Neurotrophic Factor
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Glial Cell Line-Derived Neurotrophic Factor Receptors
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Models, Molecular
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Molecular Sequence Data
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Nerve Growth Factors / chemistry
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Nerve Tissue Proteins / chemistry*
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Nerve Tissue Proteins / metabolism*
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Neurturin
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Protein Conformation
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Proto-Oncogene Proteins / chemistry
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Proto-Oncogene Proteins / metabolism*
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases / chemistry
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Receptor Protein-Tyrosine Kinases / metabolism*
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Sequence Homology, Amino Acid
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Transforming Growth Factor beta / chemistry
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Transforming Growth Factor beta / metabolism
Substances
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Bone Morphogenetic Protein 7
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Bone Morphogenetic Proteins
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Drosophila Proteins
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Glial Cell Line-Derived Neurotrophic Factor
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Glial Cell Line-Derived Neurotrophic Factor Receptors
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Nerve Growth Factors
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Nerve Tissue Proteins
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Neurturin
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Proto-Oncogene Proteins
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Transforming Growth Factor beta
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases
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Ret protein, Drosophila