X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding

Nat Struct Biol. 1997 Jun;4(6):435-8. doi: 10.1038/nsb0697-435.

Abstract

The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins / chemistry
  • Crystallography, X-Ray
  • Dimerization
  • Drosophila Proteins*
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Models, Molecular
  • Molecular Sequence Data
  • Nerve Growth Factors / chemistry
  • Nerve Tissue Proteins / chemistry*
  • Nerve Tissue Proteins / metabolism*
  • Neurturin
  • Protein Conformation
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases / chemistry
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Sequence Homology, Amino Acid
  • Transforming Growth Factor beta / chemistry
  • Transforming Growth Factor beta / metabolism

Substances

  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins
  • Drosophila Proteins
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Neurturin
  • Proto-Oncogene Proteins
  • Transforming Growth Factor beta
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Ret protein, Drosophila