BCL6 rearrangement in a patient with mantle cell lymphoma

I Miura; A Ohshima; A Chubachi; T Nimura; A Komatsuda; S Utsumi; M Saito; T Machii; S Nakamura; M Seto; A B Miura

doi:10.1007/s002770050293

BCL6 rearrangement in a patient with mantle cell lymphoma

Ann Hematol. 1997 May;74(5):247-50. doi: 10.1007/s002770050293.

Authors

I Miura¹, A Ohshima, A Chubachi, T Nimura, A Komatsuda, S Utsumi, M Saito, T Machii, S Nakamura, M Seto, A B Miura

Affiliation

¹ Third Department of Internal Medicine, Akita University School of Medicine, Japan.

PMID: 9200999
DOI: 10.1007/s002770050293

Abstract

We describe a patient with mantle cell lymphoma (MCL) associated with BCL6 gene rearrangement. MCL is a distinct subtype of non-Hodgkin's lymphoma characterized by CD5+, CD10-, CD20+, t(11;14)(q13;q32) and PRAD1/cyclin D1 overexpression. Although rearrangement of the BCL6 gene is the most frequent genetic change among diffuse lymphomas and some follicular lymphomas this is the first report of a patient with MCL associated with BCL6 rearrangement.

Publication types

Case Reports

MeSH terms

Aged
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 14
Cyclin D1
Cyclins / genetics
DNA-Binding Proteins / genetics*
Gene Rearrangement, B-Lymphocyte
Humans
Lymphoma, Non-Hodgkin / genetics*
Male
Oncogene Proteins / genetics
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-bcl-6
Transcription Factors / genetics*
Translocation, Genetic
Zinc Fingers

Substances

Cyclins
DNA-Binding Proteins
Oncogene Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-6
Transcription Factors
Cyclin D1