A high ratio of insulin-like growth factor II/insulin-like growth factor binding protein 2 messenger RNA as a marker for anaplasia in meningiomas

Cancer Res. 1997 Jul 1;57(13):2611-4.

Abstract

Insulin-like growth factors (IGFs) I and II have been implicated as autocrine or paracrine growth promoters. These growth factors bind to specific receptors, and the response is modulated by interaction with IGF-binding proteins (IGFBPs). We observed a strong correlation between anaplastic/atypical histopathology and a high IGF-II/IGFBP-2 mRNA ratio in a set of 68 sporadic meningiomas. A strong correlation was also found between clinical outcome and IGF-II/IGFBP-2 ratio, whereas previously used histochemical markers were less correlated to outcome. We suggest that a high IGF-II/IGFBP-2 mRNA ratio may be a sign of biologically aggressive behavior in meningiomas that can influence treatment strategies. We propose that low IGFBP-2 levels in combination with increased levels of IGF-II would result in more free IGF-II and consequently greater stimulation of proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anaplasia / metabolism*
  • Anaplasia / pathology
  • Blotting, Northern
  • Brain Neoplasms / metabolism*
  • Brain Neoplasms / pathology
  • Chromosome Deletion
  • Chromosomes, Human, Pair 22 / genetics
  • Female
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Insulin-Like Growth Factor Binding Protein 2 / genetics
  • Insulin-Like Growth Factor Binding Protein 2 / metabolism*
  • Insulin-Like Growth Factor II / genetics
  • Insulin-Like Growth Factor II / metabolism*
  • Ki-67 Antigen / metabolism
  • Male
  • Meningioma / metabolism*
  • Meningioma / pathology
  • Middle Aged
  • RNA, Messenger / metabolism
  • Receptors, Progesterone / metabolism

Substances

  • Insulin-Like Growth Factor Binding Protein 2
  • Ki-67 Antigen
  • RNA, Messenger
  • Receptors, Progesterone
  • Insulin-Like Growth Factor II