Neural cell adhesion molecule L1: signaling pathways and growth cone motility

J Neurosci Res. 1997 Jul 1;49(1):1-8. doi: 10.1002/(sici)1097-4547(19970701)49:1<1::aid-jnr1>3.0.co;2-h.

Abstract

The neural cell adhesion molecule L1 plays a key role in nervous system development including neuronal migration, neurite growth, and axonal fasciculation. L1 is expressed on most developing axons, and homophilic binding of L1 molecules on adjacent axons is likely to play a key role in axon extension. It is now well documented that a number of second-messenger systems are involved in L1-stimulated neurite growth in vitro. However, it is unclear how L1 homophilic or heterophilic binding trigger signals that regulate the mechanical forces that produce axon extension. In this report, we will review recent advances in understanding L1-associated signals, L1 interactions with the cytoskeleton, and the molecular mechanisms underlying growth cone motility.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cell Adhesion Molecules, Neuronal / chemistry
  • Cell Adhesion Molecules, Neuronal / physiology*
  • Cell Movement
  • Cytoskeleton / physiology
  • Dimerization
  • Humans
  • Leukocyte L1 Antigen Complex
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / physiology*
  • Mice
  • Mice, Knockout
  • Models, Neurological
  • Multigene Family
  • Neurites / physiology*
  • Signal Transduction*

Substances

  • Cell Adhesion Molecules, Neuronal
  • Leukocyte L1 Antigen Complex
  • Membrane Glycoproteins