Abstract
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adipose Tissue / metabolism
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Amino Acid Sequence
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Animals
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Caenorhabditis elegans / chemistry
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Caenorhabditis elegans / genetics*
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Caenorhabditis elegans / growth & development
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins
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Chromosome Mapping
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Conserved Sequence
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Energy Intake
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Genes, Helminth*
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Glucose / metabolism
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Humans
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Insulin / metabolism
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Larva / genetics
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Larva / growth & development
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Larva / metabolism
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Longevity / genetics*
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Molecular Sequence Data
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Mutation
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Phosphatidylinositol 3-Kinases
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Phosphatidylinositol Phosphates / metabolism
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Phosphorylation
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
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Receptor, IGF Type 1 / chemistry
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Receptor, IGF Type 1 / genetics
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Receptor, Insulin / chemistry
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Receptor, Insulin / genetics*
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Receptor, Insulin / metabolism
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Signal Transduction
Substances
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Caenorhabditis elegans Proteins
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Insulin
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Phosphatidylinositol Phosphates
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phosphatidylinositol 3,4,5-triphosphate
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Phosphatidylinositol 3-Kinases
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Phosphotransferases (Alcohol Group Acceptor)
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DAF-2 protein, C elegans
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Receptor, IGF Type 1
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Receptor, Insulin
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insulin receptor-related receptor
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Glucose