Abstract
Overexpression of the cytokine transforming growth factor-beta has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transforming growth factor-beta production. Neutralizing the actions of transforming growth factor-beta by decorin gene therapy appears to be a highly effective new approach in the treatment of renal fibrosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Angiotensin II / antagonists & inhibitors
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Animals
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Decorin
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Extracellular Matrix Proteins
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Genetic Therapy
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Humans
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Kidney Diseases / etiology
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Kidney Diseases / physiopathology
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Kidney Diseases / therapy
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Kidney Glomerulus / injuries*
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Proteoglycans / genetics
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Proteoglycans / therapeutic use
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Transforming Growth Factor beta / antagonists & inhibitors
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Transforming Growth Factor beta / physiology*
Substances
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DCN protein, human
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Decorin
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Extracellular Matrix Proteins
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Proteoglycans
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Transforming Growth Factor beta
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Angiotensin II