Positive association between the GABRA5 gene and unipolar recurrent major depression

L Oruc; G R Verheyen; I Furac; S Ivezić; M Jakovljević; P Raeymaekers; C Van Broeckhoven

doi:10.1159/000119363

Positive association between the GABRA5 gene and unipolar recurrent major depression

Neuropsychobiology. 1997;36(2):62-4. doi: 10.1159/000119363.

Authors

L Oruc¹, G R Verheyen, I Furac, S Ivezić, M Jakovljević, P Raeymaekers, C Van Broeckhoven

Affiliation

¹ Flanders Interuniversity Institute for Biotechnology, Born-Bunge Foundation, Department of Biochemistry, University of Antwerp, Belgium.

PMID: 9267853
DOI: 10.1159/000119363

Abstract

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of mood disorders. To test this hypothesis we carried out an association study between a dinucleotide repeat polymorphism in the GABAA receptor alpha 5 subunit gene and bipolar and unipolar mood disorders. Our results suggest a possible involvement of this gene in unipolar but not in bipolar disorder.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Bipolar Disorder / genetics
DNA / analysis
Depressive Disorder / genetics*
Female
Genetic Linkage
Genotype
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, GABA-A / genetics*
Recurrence

Substances

Receptors, GABA-A
DNA