Detection of 14-3-3 protein in the CSF of genetic Creutzfeldt-Jakob disease

H Rosenmann; Z Meiner; E Kahana; M Halimi; E Lenetsky; O Abramsky; R Gabizon

doi:10.1212/wnl.49.2.593

Detection of 14-3-3 protein in the CSF of genetic Creutzfeldt-Jakob disease

Neurology. 1997 Aug;49(2):593-5. doi: 10.1212/wnl.49.2.593.

Authors

H Rosenmann¹, Z Meiner, E Kahana, M Halimi, E Lenetsky, O Abramsky, R Gabizon

Affiliation

¹ Department of Neurolog, Hadassah University Hospital, Jerusalem, Israel.

PMID: 9270603
DOI: 10.1212/wnl.49.2.593

Abstract

The 14-3-3 protein, a protein involved in signal transduction, is present in the CSF of patients with Creutzfeldt-Jakob disease (CJD) and not in patients with other dementing diseases. We show here that this is also true for patients with E200K CJD, but not for healthy carriers of the mutation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

14-3-3 Proteins
Carrier State / cerebrospinal fluid
Creutzfeldt-Jakob Syndrome / cerebrospinal fluid*
Creutzfeldt-Jakob Syndrome / genetics
Humans
Immunoassay
Mutation
Nervous System Diseases / cerebrospinal fluid
Nervous System Diseases / genetics
Proteins / analysis*
Tyrosine 3-Monooxygenase*

Substances

14-3-3 Proteins
Proteins
Tyrosine 3-Monooxygenase