Role of Btk in B cell development and signaling

Curr Opin Immunol. 1997 Aug;9(4):534-40. doi: 10.1016/s0952-7915(97)80107-0.

Abstract

Bruton's tyrosine kinase (Btk), the target of inactivating mutations in X-linked immunodeficiency diseases of mice and humans, is essential for normal B cell responsiveness. Recent studies have outlined a mechanism for the activation of Btk by B cell receptor engagement and have identified proximal and distal targets of Btk action.

Publication types

  • Review

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • Animals
  • Antigens, T-Independent / immunology
  • B-Lymphocytes / cytology*
  • B-Lymphocytes / enzymology
  • Cell Differentiation
  • Enzyme Activation
  • Humans
  • Immunologic Deficiency Syndromes / enzymology*
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / immunology
  • Mice
  • Mice, Mutant Strains
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Protein-Tyrosine Kinases / physiology*
  • Signal Transduction / physiology*
  • X Chromosome / genetics
  • src-Family Kinases / physiology

Substances

  • Antigens, T-Independent
  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human
  • Btk protein, mouse
  • src-Family Kinases