Abstract
CBP, which is located on 16p13 and encodes a transcriptional adaptor/coactivator protein, has been shown to fuse by the t(8;16)(p11;p13) translocation to MOZ on 8p11 in acute myeloid leukemia. We found a t(11;16)(q23;p13) in a child with therapy-related chronic myelomonocytic leukemia. Subsequent reverse transcriptase-polymerase chain reaction and direct sequencing analyses revealed the MLL-CBP fusion transcript in CMML cells. Because 11q23 translocations involving MLL and t(8;16) involving MOZ and CBP have been reported in therapy-related leukemias, both the MLL and CBP genes may be targets for topoisomerase II inhibitors. Accordingly, we believe that most t(11;16)-associated leukemias may develop in patients who have been treated with cytotoxic chemotherapy for primary malignant diseases.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Blotting, Southern
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CREB-Binding Protein
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Child
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Chromosome Banding
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Chromosomes, Human, Pair 11 / genetics*
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Chromosomes, Human, Pair 16 / genetics*
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DNA Primers
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DNA, Neoplasm / analysis
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DNA-Binding Proteins / genetics*
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Gene Rearrangement
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Histone-Lysine N-Methyltransferase
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Humans
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Leukemia, Myelomonocytic, Chronic / chemically induced
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Leukemia, Myelomonocytic, Chronic / genetics*
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Male
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Myeloid-Lymphoid Leukemia Protein
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Neoplasms, Second Primary / genetics*
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Nuclear Proteins / genetics*
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Polymerase Chain Reaction
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Proto-Oncogenes*
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RNA-Directed DNA Polymerase
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Recombination, Genetic*
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Remission Induction
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Sequence Analysis, DNA
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Trans-Activators*
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Transcription Factors / genetics*
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Translocation, Genetic*
Substances
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DNA Primers
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DNA, Neoplasm
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DNA-Binding Proteins
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KMT2A protein, human
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Nuclear Proteins
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Trans-Activators
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Transcription Factors
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Myeloid-Lymphoid Leukemia Protein
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Histone-Lysine N-Methyltransferase
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CREB-Binding Protein
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CREBBP protein, human
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RNA-Directed DNA Polymerase