Abstract
RasGAPs supply a catalytic residue, termed the arginine finger,into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Arginine / chemistry*
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Binding Sites
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GTP Phosphohydrolases / chemistry*
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GTPase-Activating Proteins
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Guanosine Triphosphate / metabolism
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Proteins / chemistry*
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ras GTPase-Activating Proteins
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ras Proteins / chemistry*
Substances
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GTPase-Activating Proteins
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Proteins
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ras GTPase-Activating Proteins
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Guanosine Triphosphate
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Arginine
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GTP Phosphohydrolases
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ras Proteins