Abstract
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / virology
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Chemokines / genetics
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Chemokines / metabolism
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Chemokines / pharmacology
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Chemokines / physiology*
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Chemotaxis, Leukocyte
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Chick Embryo
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Eosinophils / physiology
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HIV-1 / physiology*
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Herpesvirus 8, Human / genetics*
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Herpesvirus 8, Human / physiology
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Humans
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Leukocytes, Mononuclear / virology
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Macrophage Inflammatory Proteins / genetics
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Macrophage Inflammatory Proteins / metabolism
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Macrophage Inflammatory Proteins / pharmacology
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Macrophage Inflammatory Proteins / physiology*
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Neovascularization, Pathologic / etiology*
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Neutrophils / physiology
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Receptors, CCR3
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Receptors, Chemokine*
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Receptors, Cytokine / agonists
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Receptors, Cytokine / metabolism
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Receptors, HIV / metabolism
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Tumor Cells, Cultured
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Viral Proteins*
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Virus Replication
Substances
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CCR3 protein, human
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Chemokines
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Macrophage Inflammatory Proteins
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Receptors, CCR3
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Receptors, Chemokine
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Receptors, Cytokine
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Receptors, HIV
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Viral Proteins
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vMIP-1 protein, Human herpesvirus 8
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vMIP-II