Abstract
Our former studies concerning mitochondrial DNA mutations were reviewed in this article. A 7.4 kb deletion between the D-loop and ATPase 6 genes was detected in myocardial tissue obtained at autopsy from patients with myocardial infarction, diabetes mellitus and also patients treated with adriamycin. A case with diabetes mellitus and hypertrophic cardiomyopathy is demonstrated which revealed a point mutation from adenine to guanine at position 3243 within tRNA Leu(UUR).
MeSH terms
-
Adenosine Triphosphatases / genetics
-
Cardiomyopathies / genetics*
-
DNA, Mitochondrial / genetics*
-
Diabetes Mellitus / genetics*
-
Doxorubicin / therapeutic use
-
Echocardiography
-
Female
-
Gene Deletion
-
Humans
-
Insulin / genetics
-
Middle Aged
-
Mutation*
-
Myocardial Infarction / genetics*
-
Neoplasms / drug therapy
-
Point Mutation / genetics
-
Polymerase Chain Reaction
-
RNA, Transfer, Leu / genetics*
-
Ventricular Function
Substances
-
DNA, Mitochondrial
-
Insulin
-
RNA, Transfer, Leu
-
Doxorubicin
-
Adenosine Triphosphatases