Background: A mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension.
Objective: To determine whether this observation could be confirmed with a different population sample.
Design: We examined 414 individuals with primary hypertension and 172 normotensive controls.
Methods: The mutation in the gene for the AT1 receptor was detected using restriction polymerase chain reaction.
Conclusions: We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.