5-HT1Dbeta receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina

Chest. 1998 Jan;113(1):243-4. doi: 10.1378/chest.113.1.243.

Abstract

Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1Dbeta and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1Dbeta receptor.

Publication types

  • Case Reports

MeSH terms

  • Angina Pectoris, Variant / diagnosis*
  • Angina Pectoris, Variant / metabolism
  • Angina Pectoris, Variant / physiopathology
  • Coronary Vessels / drug effects*
  • Coronary Vessels / metabolism
  • Coronary Vessels / physiopathology
  • Dose-Response Relationship, Drug
  • Drug Hypersensitivity / etiology*
  • Drug Hypersensitivity / metabolism
  • Ergonovine / administration & dosage
  • Ergonovine / adverse effects
  • Female
  • Gene Expression
  • Humans
  • Infusions, Intra-Arterial
  • Middle Aged
  • Oxytocics / administration & dosage
  • Oxytocics / adverse effects
  • RNA, Messenger / biosynthesis
  • Receptor, Serotonin, 5-HT1D
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / genetics
  • Receptors, Serotonin / metabolism*
  • Serotonin Receptor Agonists / administration & dosage
  • Serotonin Receptor Agonists / adverse effects
  • Serotonin* / administration & dosage
  • Serotonin* / adverse effects
  • Sumatriptan / administration & dosage
  • Sumatriptan / adverse effects
  • Vasoconstriction / drug effects

Substances

  • Oxytocics
  • RNA, Messenger
  • Receptor, Serotonin, 5-HT1D
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin
  • Serotonin Receptor Agonists
  • Serotonin
  • Sumatriptan
  • Ergonovine