Abstract
Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1Dbeta and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1Dbeta receptor.
MeSH terms
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Angina Pectoris, Variant / diagnosis*
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Angina Pectoris, Variant / metabolism
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Angina Pectoris, Variant / physiopathology
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Coronary Vessels / drug effects*
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Coronary Vessels / metabolism
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Coronary Vessels / physiopathology
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Dose-Response Relationship, Drug
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Drug Hypersensitivity / etiology*
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Drug Hypersensitivity / metabolism
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Ergonovine / administration & dosage
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Ergonovine / adverse effects
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Female
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Gene Expression
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Humans
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Infusions, Intra-Arterial
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Middle Aged
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Oxytocics / administration & dosage
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Oxytocics / adverse effects
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RNA, Messenger / biosynthesis
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Receptor, Serotonin, 5-HT1D
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / genetics
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Receptors, Serotonin / metabolism*
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Serotonin Receptor Agonists / administration & dosage
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Serotonin Receptor Agonists / adverse effects
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Serotonin* / administration & dosage
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Serotonin* / adverse effects
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Sumatriptan / administration & dosage
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Sumatriptan / adverse effects
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Vasoconstriction / drug effects
Substances
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Oxytocics
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RNA, Messenger
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Receptor, Serotonin, 5-HT1D
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin
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Serotonin Receptor Agonists
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Serotonin
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Sumatriptan
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Ergonovine