Abstract
Multiple mtDNA deletions have been reported to be a cause of inherited recurrent myoglobinuria. We report a 57-year-old man with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions who developed acute rhabdomyolysis provoked by alcohol. A repeated alcohol intake resulted in a 57-fold increase in serum myoglobin. Patients with mitochondrial myopathy and multiple mtDNA deletions, regardless of associated phenotype and mode of inheritance, may develop rhabdomyolysis.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Kidney Injury / etiology
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Acute Kidney Injury / therapy
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Central Nervous System Depressants / adverse effects*
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Chromosome Aberrations
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Chromosome Disorders
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DNA, Mitochondrial / genetics
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Ethanol / adverse effects*
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Gene Deletion
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Genes, Dominant
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Humans
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Male
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Middle Aged
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Myoglobinuria / blood
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Myoglobinuria / etiology
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Ophthalmoplegia / complications
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Ophthalmoplegia / genetics*
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Renal Dialysis
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Rhabdomyolysis / chemically induced*
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Rhabdomyolysis / genetics*
Substances
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Central Nervous System Depressants
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DNA, Mitochondrial
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Ethanol