Apolipoprotein E gene in Parkinson's disease, Lewy body dementia and Alzheimer's disease

J Neural Transm Suppl. 1997:51:161-5. doi: 10.1007/978-3-7091-6846-2_13.

Abstract

Apolipoprotein E (Apo E) epsilon 4 allele is a risk factor for early and late onset Alzheimer's disease. This prompted us to examine other neurophyschiatric phenotypes. Epsilon 4 allele was significantly enriched in Lewy body dementia (n = 39) but not in Parkinson's disease (n = 50) or Schizophrenia (n = 175) compared to aged non-demented controls (n = 47) and the Scottish population (n = 400). We conclude that Lewy body disease should be regarded as a variant of Alzheimer's but not Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Apolipoproteins E / genetics*
  • Apolipoproteins E / metabolism
  • Dementia / genetics
  • Dementia / pathology
  • Female
  • Humans
  • Lewy Bodies / genetics*
  • Lewy Bodies / metabolism
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Middle Aged
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism
  • Presenilin-1
  • Risk Factors
  • Schizophrenia / genetics
  • Schizophrenia / metabolism

Substances

  • Apolipoproteins E
  • Membrane Proteins
  • PSEN1 protein, human
  • Presenilin-1