Abstract
Breast and gynecological cancer-associated antigens RAK p120, p42 and p25 exhibit molecular, immunological and genetic homology to HIV-1 proteins. Normal tissues, including the majority of tissues adjacent to cancer, do not express these unique cancer markers. Antigens RAK are now detected in 100% of prostate cancer and in the majority of prostate benign hyperplasia (BPH) cases. Polymerase chain reaction (PCR) with HIV-1 gp41-derived primers revealed prostate cancer-associated DNA fragments of similar size (140 bp) as in HIV-1 genome. Ninety-five percent of BPH samples obtained from prostate cancer patients tested PCR-positive. For comparison, only 61.9% of BPH samples obtained from cancer-free patients tested PCR-positive. The DNA fragments amplified in prostate cancer and in BPH showed more than 90% homology to the HIV-1 gene for gp41. The obtained results strongly suggest that a retrovirus related to HIV-1 may be associated with cancers of the reproductive system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Neoplasm / analysis*
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Antigens, Neoplasm / genetics*
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Base Sequence
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Biomarkers, Tumor / analysis*
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Biomarkers, Tumor / genetics
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Breast Neoplasms / chemistry*
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Breast Neoplasms / genetics
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Chromobox Protein Homolog 5
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DNA Primers
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DNA, Neoplasm / genetics
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Female
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Genital Neoplasms, Female / chemistry*
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Genital Neoplasms, Female / genetics
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HIV Envelope Protein gp41 / genetics*
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Humans
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Male
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Molecular Sequence Data
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Neoplasm Proteins*
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Prostatic Hyperplasia / genetics
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Prostatic Hyperplasia / metabolism
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Prostatic Neoplasms / chemistry*
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Prostatic Neoplasms / genetics
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Protein-Tyrosine Kinases / analysis*
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Protein-Tyrosine Kinases / genetics*
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Sequence Homology, Nucleic Acid
Substances
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Antigens, Neoplasm
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Biomarkers, Tumor
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CBX5 protein, human
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DNA Primers
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DNA, Neoplasm
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HIV Envelope Protein gp41
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Neoplasm Proteins
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Chromobox Protein Homolog 5
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Protein-Tyrosine Kinases
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FRK protein, human
Associated data
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GENBANK/AF048697
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GENBANK/AF048842
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GENBANK/AF048843
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GENBANK/AF048844
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GENBANK/AF048845
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GENBANK/AF048846
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GENBANK/AF073463
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GENBANK/AF073464
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GENBANK/AF073465
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GENBANK/AF073466
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GENBANK/AF073467
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GENBANK/AF073468
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GENBANK/AF073469