The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions

V I Kulikov; G I Muzya

The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions

Biochemistry (Mosc). 1998 Jan;63(1):47-54.

Authors

V I Kulikov¹, G I Muzya

Affiliation

¹ Research and Development Center for Medical Biotechnology, Ministry of Health of the Russian Federation, Moscow, Russia.

PMID: 9526094

Abstract

The role of platelet-activating factor (PAF, a phospholipid compound) in regulation of cell functions and cell-cell interactions is reviewed. The biological effects of PAF on platelets, neutrophils, basophils, eosinophiles, lymphocytes, and endothelial cells are described. Mechanisms of cell activation by PAF are discussed. Interactions of PAF with other biological regulators (prostaglandins, leukotrienes, NO, tumor necrosis factor, and interleukins) are considered.

Publication types

Review

MeSH terms

Animals
Cell Communication / physiology
Drug Interactions
Endothelium, Vascular / drug effects
Endothelium, Vascular / physiology
Humans
In Vitro Techniques
Leukocytes / drug effects
Leukocytes / physiology
Platelet Activating Factor / analogs & derivatives
Platelet Activating Factor / pharmacology
Platelet Activating Factor / physiology*
Platelet Activation / drug effects
Platelet Activation / physiology
Platelet Membrane Glycoproteins / physiology
Receptors, Cell Surface*
Receptors, G-Protein-Coupled*

Substances

Platelet Activating Factor
Platelet Membrane Glycoproteins
Receptors, Cell Surface
Receptors, G-Protein-Coupled
platelet activating factor receptor