Abstract
Ret/PTC oncogene has been described with a frequency of 2.5-30% in papillary thyroid carcinomas. We examined the expression of ret/PTC in 99 German papillary thyroid carcinomas, including two recently described new variants of ret/PTC3 and identified eight ret/PTC-positive tumours (8%) but none with the new variants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Artificial Gene Fusion
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Carcinoma, Papillary / genetics
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Carcinoma, Papillary / metabolism*
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Drosophila Proteins*
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Germany
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Humans
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Nuclear Receptor Coactivators
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Oncogene Proteins / biosynthesis*
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Oncogene Proteins, Fusion
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Oncogenes
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Polymerase Chain Reaction
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins / biosynthesis*
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Proto-Oncogene Proteins c-ret
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Proto-Oncogenes
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Receptor Protein-Tyrosine Kinases / biosynthesis*
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Sequence Deletion
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Thyroid Neoplasms / genetics
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Thyroid Neoplasms / metabolism*
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Transcription Factors*
Substances
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Drosophila Proteins
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NCOA4 protein, human
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Nuclear Receptor Coactivators
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Oncogene Proteins
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Oncogene Proteins, Fusion
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Proto-Oncogene Proteins
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Transcription Factors
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Protein-Tyrosine Kinases
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Proto-Oncogene Proteins c-ret
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RET protein, human
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Receptor Protein-Tyrosine Kinases
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Ret protein, Drosophila
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ret-PTC fusion oncoproteins, human