Abstract
Coenzyme Q10 was administered under placebo controlled blinded crossover conditions to six subjects suffering from type 3 3-methylglutaconic aciduria ('optic atrophy plus'), following a report of benefit. Despite attainment of high plasma levels of coenzyme Q10, no clinical benefit was observed and there was no diminution of urinary excretion of 3-methylglutaconic acid.
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Child
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Coenzymes
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Cross-Over Studies
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Female
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Glutarates / urine*
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Humans
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Male
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Movement Disorders / complications
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Neuromuscular Diseases / complications
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Optic Atrophy / complications
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Single-Blind Method
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Treatment Failure
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Ubiquinone / analogs & derivatives*
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Ubiquinone / blood
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Ubiquinone / therapeutic use
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Visual Acuity / drug effects
Substances
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Coenzymes
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Glutarates
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Ubiquinone
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3-methylglutaconic acid
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coenzyme Q10