Abstract
Susceptibility to coeliac disease is associated with a particular HLA-DQ alpha beta heterodimer encoded by the DQA1*0501 and DQB1*02 genes. A single base polymorphism in the DQB1*02 promoter region in DR7, DQA1*0201, DQB1*02 haplotypes was observed, associated with an increased susceptibility to the disease. This finding suggests a novel mechanism of susceptibility to immune-mediated diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Base Sequence
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Celiac Disease / genetics*
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Cell Line
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DNA / analysis
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Gene Expression Regulation
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Genetic Predisposition to Disease
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HLA-DQ Antigens / genetics*
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HLA-DQ alpha-Chains
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HLA-DQ beta-Chains
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HLA-DR7 Antigen / genetics
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Haplotypes
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Humans
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Leukocytes
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Molecular Sequence Data
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Polymorphism, Genetic*
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Promoter Regions, Genetic*
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Transcription, Genetic
Substances
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HLA-DQ Antigens
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HLA-DQ alpha-Chains
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HLA-DQ beta-Chains
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HLA-DQA1 antigen
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HLA-DQB1 antigen
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HLA-DR7 Antigen
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DNA