Angiotensin-converting enzyme gene polymorphism in systemic hypertension

Z A Abbud; A C Wilson; N M Cosgrove; J B Kostis

doi:10.1016/s0002-9149(97)00876-x

Angiotensin-converting enzyme gene polymorphism in systemic hypertension

Am J Cardiol. 1998 Jan 15;81(2):244-6. doi: 10.1016/s0002-9149(97)00876-x.

Authors

Z A Abbud¹, A C Wilson, N M Cosgrove, J B Kostis

Affiliation

¹ TONE Clinical Center, Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903-0019, USA.

PMID: 9591915
DOI: 10.1016/s0002-9149(97)00876-x

Abstract

We determined the angiotensin-converting enzyme (ACE) insertion/deletion genotype in 209 hypertensive individuals and in 100 matched normotensive controls. A significant association was detected between hypertension and the deletion/deletion (D/D) genotype of the ACE gene when the relation was adjusted for age, sex, and body mass index.

Publication types

Comparative Study
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aged
Aged, 80 and over
Blood Pressure
DNA / analysis*
DNA Probes / chemistry
Genotype
Humans
Hypertension / enzymology*
Hypertension / genetics
Middle Aged
Odds Ratio
Peptidyl-Dipeptidase A / blood
Peptidyl-Dipeptidase A / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Random Allocation
Reproducibility of Results

Substances

DNA Probes
DNA
Peptidyl-Dipeptidase A