Association of primary antiphospholipid syndrome with inherited activated protein C resistance

J Rheumatol. 1998 Jun;25(6):1232-4.

Abstract

A 65-year-old man had had arterial thromboses of the lower limbs and cerebral region for several years; tests revealed anticardiolipin, antiphosphatidylserine, anti-beta2-glycoprotein I antibodies, and lupus anticoagulant. As well, both phenotypic and genotypic resistance to activated protein C was found. Antiphospholipid antibodies have been reported to interfere in different ways with the functions of protein C; in our patient the simultaneous existence of inherited resistance to activated protein C could account for the thrombophilic status underlying the diffuse and serious arterial thromboses.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Anticardiolipin / analysis
  • Antibodies, Antiphospholipid / analysis
  • Antiphospholipid Syndrome / blood
  • Antiphospholipid Syndrome / complications*
  • Antiphospholipid Syndrome / pathology
  • Factor V / genetics*
  • Glycoproteins / immunology
  • Humans
  • Lupus Coagulation Inhibitor / blood
  • Magnetic Resonance Imaging
  • Male
  • Mutation*
  • Protein C / genetics*
  • Thromboembolism / complications*
  • Thromboembolism / genetics
  • Thromboembolism / pathology
  • Thrombophilia / complications*
  • Thrombophilia / genetics
  • Thrombophilia / pathology
  • beta 2-Glycoprotein I

Substances

  • Antibodies, Anticardiolipin
  • Antibodies, Antiphospholipid
  • Glycoproteins
  • Lupus Coagulation Inhibitor
  • Protein C
  • beta 2-Glycoprotein I
  • factor V Leiden
  • Factor V