Abstract
A new antiulcer agent, ecabet sodium is one of dehydroabietic acid derivatives prepared from pine resin. The effects of ecabet sodium on colorectal carcinogenesis were investigated in azoxymethane-pretreated mice with chronic ulcerative colitis induced by 3 repeated administration of 3% dextran sulfate sodium and in 1, 2-dimethylhydrazine-treated rats. Although daily treatment with ecabet sodium did not affect the colorectal DNA-synthesizing enzyme activities and bromodeoxyuridine-immunoreactive S-phase cells, high-grade dysplasia in ecabet sodium-treated mice was less frequent than in untreated mice. In rats, ecabet sodium administration reduced the elevated activity of thymidylate synthetase in colorectal tumors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1,2-Dimethylhydrazine
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Abietanes*
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Animals
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Anticarcinogenic Agents / therapeutic use*
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Azoxymethane
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Body Weight / drug effects
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Carcinogens
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Colitis, Ulcerative / chemically induced
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Colitis, Ulcerative / complications*
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Colon / drug effects
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Colon / pathology
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Colorectal Neoplasms / chemically induced
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Colorectal Neoplasms / enzymology
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / prevention & control*
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Diterpenes / therapeutic use*
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Female
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / pathology*
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Male
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Mice
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Mice, Inbred CBA
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Organ Size / drug effects
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Precancerous Conditions / chemically induced
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Precancerous Conditions / pathology
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Precancerous Conditions / prevention & control
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Rats
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Rats, Inbred Strains
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Rectum / drug effects
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Rectum / pathology
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Thymidylate Synthase / antagonists & inhibitors
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Thymidylate Synthase / biosynthesis
Substances
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Abietanes
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Anticarcinogenic Agents
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Carcinogens
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Diterpenes
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ecabet
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Thymidylate Synthase
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1,2-Dimethylhydrazine
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Azoxymethane