The pathophysiological role of estrogen receptor variants in human breast cancer

J Steroid Biochem Mol Biol. 1998 Apr;65(1-6):175-80. doi: 10.1016/s0960-0760(98)00012-0.

Abstract

The accumulated evidence supports the expression of estrogen receptor variants at both the mRNA and protein levels. The relative level of expression of some estrogen receptor variant mRNAs and possibly progesterone receptor variant mRNAs is altered during breast tumorigenesis and breast cancer progression. The altered expression of estrogen receptor variants may effect estrogen signal transduction as well as the interpretation of assays where the estimation of estrogen receptor levels is used as a guide to treatment strategies and prognosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / physiopathology*
  • Female
  • Gene Expression
  • Genetic Variation*
  • Humans
  • RNA, Messenger / genetics
  • Receptors, Estrogen / genetics*
  • Receptors, Progesterone / genetics

Substances

  • RNA, Messenger
  • Receptors, Estrogen
  • Receptors, Progesterone