Identification of BCR-ABL fusion on chromosome 9 by fluorescence in situ hybridization in two chronic myeloid leukemia cases

E Abruzzese; M J Pettenati; K Cox; B Jackle; R G Watts; A J Carroll; M C Steuterman; P N Rao

doi:10.1016/s0165-4608(98)00020-x

Identification of BCR-ABL fusion on chromosome 9 by fluorescence in situ hybridization in two chronic myeloid leukemia cases

Cancer Genet Cytogenet. 1998 Sep;105(2):164-7. doi: 10.1016/s0165-4608(98)00020-x.

Authors

E Abruzzese¹, M J Pettenati, K Cox, B Jackle, R G Watts, A J Carroll, M C Steuterman, P N Rao

Affiliation

¹ Department of Cancer Biology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA.

PMID: 9723035
DOI: 10.1016/s0165-4608(98)00020-x

Abstract

We present two cases with hidden Philadelphia translocations that resulted from an insertion and a complex translocation. These cases were unusual in having the BCR/ABL fusion localized to chromosome 9q34. A review of cases with these uncommon presentations of BCR/ABL and prognostic presentation is presented.

Publication types

Case Reports
Review

MeSH terms

Adolescent
Chromosomes, Human, Pair 9*
Female
Fusion Proteins, bcr-abl / genetics*
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
Male
Middle Aged
Philadelphia Chromosome

Substances

Fusion Proteins, bcr-abl