MTHFR association with arteriosclerotic vascular disease?

O Fletcher; A M Kessling

doi:10.1007/s004390050776

MTHFR association with arteriosclerotic vascular disease?

Hum Genet. 1998 Jul;103(1):11-21. doi: 10.1007/s004390050776.

Authors

O Fletcher¹, A M Kessling

Affiliation

¹ Medical and Community Genetics, Imperial College School of Medicine, Northwick Park and St. Mark's NHS Trust, Harrow, UK.

PMID: 9737770
DOI: 10.1007/s004390050776

Abstract

Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alleles
Arteriosclerosis / blood
Arteriosclerosis / genetics*
Databases, Bibliographic
Folic Acid / blood
Genetic Predisposition to Disease
Homocysteine / blood
Homozygote
Humans
MEDLINE
Methylenetetrahydrofolate Reductase (NADPH2)
Oxidoreductases Acting on CH-NH Group Donors / genetics*
Point Mutation*

Substances

Homocysteine
Folic Acid
Oxidoreductases Acting on CH-NH Group Donors
Methylenetetrahydrofolate Reductase (NADPH2)