Abstract
The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil. Also, there was a significant association between isolation of cagA+ s1-type vacA H. pylori in cases of stomach cancer and ulcers as opposed to cases of gastritis only (P = 0.004), but this was not true in Houston (P = 0.238), where 94% of all isolates were cagA+.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Alleles
-
Antigens, Bacterial*
-
Bacterial Proteins / genetics*
-
Base Sequence
-
Brazil / epidemiology
-
DNA Primers / genetics
-
Duodenal Ulcer / complications
-
Duodenal Ulcer / microbiology*
-
Gastritis / complications
-
Gastritis / microbiology*
-
Genes, Bacterial
-
Helicobacter Infections / complications
-
Helicobacter Infections / epidemiology
-
Helicobacter Infections / microbiology*
-
Helicobacter pylori / genetics*
-
Helicobacter pylori / isolation & purification*
-
Humans
-
Molecular Epidemiology
-
Polymerase Chain Reaction
-
Stomach Neoplasms / complications
-
Stomach Neoplasms / microbiology*
-
Texas / epidemiology
Substances
-
Antigens, Bacterial
-
Bacterial Proteins
-
DNA Primers
-
VacA protein, Helicobacter pylori
-
cagA protein, Helicobacter pylori