Abstract
Fifteen patients with primary GH resistance (Laron syndrome, LS) were studied before and during 6 months of daily replacement treatment with IGF-I. The main findings were that patients with LS and normal or high serum GH binding protein (GHBP) were less obese than those with a negative GHBP, and that serum leptin levels varied with body mass as in other types of obesity.
MeSH terms
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Adult
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Body Composition
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Carrier Proteins / blood
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Child
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Child, Preschool
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Drug Resistance
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Female
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Human Growth Hormone
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Humans
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Infant
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Insulin / blood
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Insulin-Like Growth Factor I / analysis
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Insulin-Like Growth Factor I / deficiency
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Insulin-Like Growth Factor I / therapeutic use*
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Leptin
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Male
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Mutation*
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Obesity / blood*
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Obesity / drug therapy
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Obesity / genetics*
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Proteins / analysis*
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Receptors, Leptin
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Receptors, Somatotropin / genetics*
Substances
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Carrier Proteins
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Insulin
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LEPR protein, human
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Leptin
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Proteins
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Receptors, Leptin
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Receptors, Somatotropin
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Human Growth Hormone
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Insulin-Like Growth Factor I
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somatotropin-binding protein