Abstract
A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported. By FISH analysis, the human ID4 gene was more precisely mapped to chromosome 6p22.3-p23. Northern blot analysis showed that ID4 is mainly expressed in thyroid, brain and fetal tissue and in some nervous system tumor cell lines.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Northern
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Brain / metabolism
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Chromosome Mapping*
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Chromosomes, Human, Pair 6*
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Cloning, Molecular*
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DNA, Complementary / genetics
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DNA, Complementary / isolation & purification
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DNA-Binding Proteins*
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Fetus / metabolism
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Gene Expression Regulation, Developmental
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Humans
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In Situ Hybridization, Fluorescence
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Inhibitor of Differentiation Proteins
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Mice
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Molecular Sequence Data
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Nervous System Neoplasms / genetics
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Proteins / chemistry
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Proteins / genetics*
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Proteins / metabolism
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Sequence Analysis, DNA
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Thyroid Gland / metabolism
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Transcription Factors*
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Tumor Cells, Cultured
Substances
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DNA, Complementary
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DNA-Binding Proteins
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ID4 protein, human
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Idb4 protein, mouse
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Inhibitor of Differentiation Proteins
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Proteins
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Transcription Factors