Abstract
Mutations of a novel MHC class I-like protein, termed HFE, have been found in the vast majority of patients with the iron overload disease heredity hemochromatosis. Identification of HFE is likely to shed light on one of the major enigmas of mammalian iron homeostasis: How is intestinal iron absorption regulated?
MeSH terms
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Animals
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HLA Antigens / genetics*
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HLA Antigens / metabolism*
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Hemochromatosis / genetics*
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Hemochromatosis Protein
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class I / metabolism*
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Homeostasis
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Humans
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Iron / metabolism*
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Membrane Proteins*
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Receptors, Transferrin / metabolism*
Substances
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HFE protein, human
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HLA Antigens
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Hemochromatosis Protein
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Histocompatibility Antigens Class I
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Membrane Proteins
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Receptors, Transferrin
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Iron