Antibodies prepared to neuronal glutamate receptor subunit3 bind IFNalpha-receptors: implications for an autoimmune process

Autoimmunity. 1998;28(4):243-8. doi: 10.3109/08916939808995372.

Abstract

Anti-glutamate receptor (GluR) agonist-like antibodies prepared in rabbits that are similar to autoantibodies found in Rasmussen's encephalitis (RE) were found to exhibit greater immunoreactivity towards human interferon alpha receptor (IFNAR-1) than to GluR3. Since antibodies prepared to a defined region of GluR3 can react preferentially to an unrelated sequence in the human IFNAR-1, we propose that the IFNAR-1 may be an heteroclitic antigen of GluR3. These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoantibodies / immunology*
  • Autoimmunity / immunology
  • Cattle
  • Encephalitis / blood
  • Encephalitis / immunology
  • Humans
  • Mice
  • Molecular Sequence Data
  • Neurons / immunology*
  • Rabbits
  • Receptor, Interferon alpha-beta
  • Receptors, Glutamate / immunology*
  • Receptors, Interferon / genetics
  • Receptors, Interferon / immunology*

Substances

  • Autoantibodies
  • Receptors, Glutamate
  • Receptors, Interferon
  • Receptor, Interferon alpha-beta