Acute myeloid leukemia with hypergranular cytoplasm accompanied by t(X;11)(q24;q23) and rearrangement of the MLL gene

Leuk Res. 1999 Jan;23(1):85-8. doi: 10.1016/s0145-2126(98)00131-3.

Abstract

This report describes a unique case of acute myeloid leukemia with hypergranular cytoplasm and t(X;11)(q24;q23). The breakpoint on 11q23 was identified within the MLL gene. The hypergranular cytoplasm of leukemic cells and the associated coagulopathy resembled a characteristic of acute promyelocytic leukemia, despite the absence of RARalpha gene rearrangement in this case. The Xq24 site possibly played a role in this atypical blast phenotype.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Child
  • DNA-Binding Proteins / genetics*
  • Disseminated Intravascular Coagulation / complications
  • Gene Rearrangement
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Karyotyping
  • Leukemia, Myeloid / complications
  • Leukemia, Myeloid / drug therapy
  • Leukemia, Myeloid / genetics*
  • Male
  • Myeloid-Lymphoid Leukemia Protein
  • Proto-Oncogenes*
  • Remission Induction
  • Transcription Factors*
  • Translocation, Genetic*

Substances

  • DNA-Binding Proteins
  • KMT2A protein, human
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase