New DNA polymorphisms of human MMH/OGG1 gene: prevalence of one polymorphism among lung-adenocarcinoma patients in Japanese

Int J Cancer. 1999 Jan 5;80(1):18-21. doi: 10.1002/(sici)1097-0215(19990105)80:1<18::aid-ijc4>3.0.co;2-e.

Abstract

MMH/OGG1 is an 8-hydroxyguanine-specific DNA glycosylase/AP-lyase, one of the mutator enzymes for the excision repair of 8-hydroxyguanine. DNA polymorphisms in human MMH/OGG1 gene were newly identified and analyzed to examine a possible association with lung-cancer risk by a population-based study. Polymorphic allele 3 in hMMH/OGG1 exon 1 was significantly prevalent among Japanese patients with adenocarcinoma of the lung [odds ratio (OR): 3.152, 95% confidence interval (CI): 1.266-7.845], indicating that the excision repair of 8-hydroxyguanine may play a role in predisposition to lung cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / enzymology
  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / genetics*
  • Adenocarcinoma / surgery
  • Base Sequence
  • Carcinoma, Non-Small-Cell Lung / enzymology
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / surgery
  • Carcinoma, Squamous Cell / enzymology
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / surgery
  • DNA-Formamidopyrimidine Glycosylase
  • Exons
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Japan / epidemiology
  • Lung Neoplasms / enzymology
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / surgery
  • Male
  • N-Glycosyl Hydrolases / genetics*
  • Odds Ratio
  • Polymorphism, Genetic*
  • Polymorphism, Single-Stranded Conformational
  • Reference Values
  • Risk Factors

Substances

  • N-Glycosyl Hydrolases
  • DNA-Formamidopyrimidine Glycosylase