Abstract
MMH/OGG1 is an 8-hydroxyguanine-specific DNA glycosylase/AP-lyase, one of the mutator enzymes for the excision repair of 8-hydroxyguanine. DNA polymorphisms in human MMH/OGG1 gene were newly identified and analyzed to examine a possible association with lung-cancer risk by a population-based study. Polymorphic allele 3 in hMMH/OGG1 exon 1 was significantly prevalent among Japanese patients with adenocarcinoma of the lung [odds ratio (OR): 3.152, 95% confidence interval (CI): 1.266-7.845], indicating that the excision repair of 8-hydroxyguanine may play a role in predisposition to lung cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / enzymology
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Adenocarcinoma / epidemiology
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Adenocarcinoma / genetics*
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Adenocarcinoma / surgery
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Base Sequence
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Carcinoma, Non-Small-Cell Lung / enzymology
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Carcinoma, Non-Small-Cell Lung / genetics*
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Carcinoma, Non-Small-Cell Lung / surgery
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Carcinoma, Squamous Cell / enzymology
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / surgery
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DNA-Formamidopyrimidine Glycosylase
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Exons
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Female
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Genetic Predisposition to Disease
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Humans
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Japan / epidemiology
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Lung Neoplasms / enzymology
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Lung Neoplasms / epidemiology
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Lung Neoplasms / genetics*
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Lung Neoplasms / surgery
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Male
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N-Glycosyl Hydrolases / genetics*
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Odds Ratio
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Polymorphism, Genetic*
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Polymorphism, Single-Stranded Conformational
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Reference Values
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Risk Factors
Substances
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N-Glycosyl Hydrolases
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DNA-Formamidopyrimidine Glycosylase