Abstract
The role of interleukin (IL)-11, a cytokine with potent anti-inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme carditis was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-gamma or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Inflammatory Agents
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Antibodies, Monoclonal / pharmacology
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Arthritis, Infectious / etiology
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Arthritis, Infectious / therapy*
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Female
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Humans
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Inflammation
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Interferon-gamma / genetics
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Interleukin-11 / therapeutic use*
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Interleukin-12 / genetics
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Interleukin-4 / genetics
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Lyme Disease / physiopathology*
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Lyme Disease / therapy*
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Mice
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Mice, Inbred C3H
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Myocarditis / microbiology*
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Myocarditis / physiopathology
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Nitric Oxide Synthase / genetics
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Nitric Oxide Synthase Type II
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RNA, Messenger / genetics
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Recombinant Proteins / therapeutic use
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Transcription, Genetic
Substances
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Anti-Inflammatory Agents
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Antibodies, Monoclonal
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Interleukin-11
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RNA, Messenger
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Recombinant Proteins
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Interleukin-12
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Interleukin-4
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Interferon-gamma
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NOS2 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse