PXD010715

PXD010715 is an original dataset announced via ProteomeXchange.

Title	Molecular profiling of innate immune response mechanisms in ventilator associated pneumonia (VAP)
Description	Ventilator associated pneumonia (VAP) is the 2nd most common hospital acquired infection associated with high morbidity, mortality and increased hospitalization. Current practice of diagnosis is based on clinical symptoms and bronchoalvolar lavage (BAL) culture. The procedures of BAL collections are invasive whereas, endotracheal aspirate (ETA), a matrix of upper airway collection is minimally invasive and underexplored in VAP diagnosis. The study describes first in detail characterization of proteome of longitudinal ETA collections from 16 intubated patients including 11 VAP patients and explores potential utility of ETA in VAP diagnosis.
HostingRepository	PRIDE
AnnounceDate	2020-07-27
AnnouncementXML	Submission_2020-07-27_04:45:45.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Krystine Mansfield
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-08-07 07:53:51	ID requested
⏵ 1	2020-07-27 04:45:46	announced

Pathak KV, McGilvrey MI, Hu CK, Garcia-Mansfield K, Lewandoski K, Eftekhari Z, Yuan YC, Zenhausern F, Menashi E, Pirrotte P, Molecular Profiling of Innate Immune Response Mechanisms in Ventilator-associated Pneumonia. Mol Cell Proteomics, 19(10):1688-1705(2020) [pubmed]

submitter keyword: LC-MS/MS, endotracheal aspirates, bronchoalveolar lavage, ventilator associated pneumonia

Patrick Pirrotte
contact affiliation	Translational Genomics Research Institute, Phoenix, AZ, USA
contact email	ppirrotte@tgen.org
lab head
Krystine Mansfield
contact affiliation	Translational Genomics Research Institute, Phoenix, AZ, USA
contact email	kgarcia@tgen.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD010715

PRIDE project URI

• PRIDE
  1. PXD010715
     1. Label: PRIDE project
     2. Name: Molecular profiling of innate immune response mechanisms in ventilator associated pneumonia (VAP)