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About
What is Reactome ?
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Team
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Release Calendar
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Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
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AscH- [cytosol]
Stable Identifier
R-ALL-198816
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Ascorbate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
FIH1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Bos taurus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Bos taurus)
VBC complex (with or without LIMD1) [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Bos taurus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Bos taurus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Bos taurus)
PHD2,3 [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Carnitine synthesis (Bos taurus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
BBOX1:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Bos taurus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Bos taurus)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Tyrosine catabolism (Bos taurus)
HPD dioxygenates HPP (Bos taurus)
HPD:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ dimer [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ [cytosol] (Bos taurus)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Vitamin C (ascorbate) metabolism (Bos taurus)
CYB5A:heme reduces Asc.- to AscH- (Bos taurus)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Bos taurus)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)
AscH- [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
VBC complex (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
PHD2,3 [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Carnitine synthesis (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Caenorhabditis elegans)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Caenorhabditis elegans)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Tyrosine catabolism (Caenorhabditis elegans)
HPD dioxygenates HPP (Caenorhabditis elegans)
HPD:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ dimer [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Vitamin C (ascorbate) metabolism (Caenorhabditis elegans)
CYB5A:heme reduces Asc.- to AscH- (Caenorhabditis elegans)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Caenorhabditis elegans)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
AscH- [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)
FIH1:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
FIH1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Canis familiaris)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
VBC complex (with or without LIMD1) [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Canis familiaris)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Canis familiaris)
PHD2,3 [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Carnitine synthesis (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
BBOX1:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Canis familiaris)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Canis familiaris)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Tyrosine catabolism (Canis familiaris)
HPD dioxygenates HPP (Canis familiaris)
HPD:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ dimer [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ [cytosol] (Canis familiaris)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Vitamin C (ascorbate) metabolism (Canis familiaris)
CYB5A:heme reduces Asc.- to AscH- (Canis familiaris)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Canis familiaris)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Canis familiaris)
AscH- [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to hypoxia (Danio rerio)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)
FIH1:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
FIH1:AscH-:Fe2+ [cytosol] (Danio rerio)
AscH- [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Carnitine synthesis (Danio rerio)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
BBOX1:AscH-:Fe2+ [cytosol] (Danio rerio)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Tyrosine catabolism (Danio rerio)
HPD dioxygenates HPP (Danio rerio)
HPD:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ [cytosol] (Danio rerio)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ dimer [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ [cytosol] (Danio rerio)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Vitamin C (ascorbate) metabolism (Danio rerio)
CYB5A:heme reduces Asc.- to AscH- (Danio rerio)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Danio rerio)
AscH- [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Tyrosine catabolism (Dictyostelium discoideum)
HPD dioxygenates HPP (Dictyostelium discoideum)
HPD:AscH-:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ [cytosol] (Dictyostelium discoideum)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ dimer [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ [cytosol] (Dictyostelium discoideum)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Vitamin C (ascorbate) metabolism (Dictyostelium discoideum)
CYB5A:heme reduces Asc.- to AscH- (Dictyostelium discoideum)
AscH- [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)
VBC complex (with or without LIMD1) [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Drosophila melanogaster)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Drosophila melanogaster)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Drosophila melanogaster)
PHD2,3 [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Carnitine synthesis (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Drosophila melanogaster)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Drosophila melanogaster)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Tyrosine catabolism (Drosophila melanogaster)
HPD dioxygenates HPP (Drosophila melanogaster)
HPD:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ dimer [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Vitamin C (ascorbate) metabolism (Drosophila melanogaster)
CYB5A:heme reduces Asc.- to AscH- (Drosophila melanogaster)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
AscH- [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to hypoxia (Gallus gallus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
FIH1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Gallus gallus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
PHD2,3 [cytosol] (Gallus gallus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Carnitine synthesis (Gallus gallus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Gallus gallus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
BBOX1:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Gallus gallus)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Gallus gallus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Gallus gallus)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Tyrosine catabolism (Gallus gallus)
HPD dioxygenates HPP (Gallus gallus)
HPD:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ dimer [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ [cytosol] (Gallus gallus)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Vitamin C (ascorbate) metabolism (Gallus gallus)
CYB5A:heme reduces Asc.- to AscH- (Gallus gallus)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Gallus gallus)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Gallus gallus)
AscH- [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)
FIH1:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Carnitine synthesis (Homo sapiens)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
BBOX1:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Homo sapiens)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Homo sapiens)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Tyrosine catabolism (Homo sapiens)
HPD dioxygenates HPP (Homo sapiens)
HPD:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)
AscH- [cytosol]
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Vitamin C (ascorbate) metabolism (Homo sapiens)
Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)
AscH- [cytosol]
CYB5A:heme reduces Asc.- to AscH- (Homo sapiens)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Homo sapiens)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Homo sapiens)
AscH- [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
FIH1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Mus musculus)
VBC complex (with or without LIMD1) [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
PHD2,3 [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Carnitine synthesis (Mus musculus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
BBOX1:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Mus musculus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Mus musculus)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Tyrosine catabolism (Mus musculus)
HPD dioxygenates HPP (Mus musculus)
HPD:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ dimer [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ [cytosol] (Mus musculus)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Vitamin C (ascorbate) metabolism (Mus musculus)
CYB5A:heme reduces Asc.- to AscH- (Mus musculus)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Mus musculus)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)
AscH- [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to hypoxia (Rattus norvegicus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)
FIH1:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
FIH1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)
VBC complex (with or without LIMD1) [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
PHD2,3 [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Carnitine synthesis (Rattus norvegicus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
BBOX1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Rattus norvegicus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Rattus norvegicus)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Tyrosine catabolism (Rattus norvegicus)
HPD dioxygenates HPP (Rattus norvegicus)
HPD:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ dimer [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Vitamin C (ascorbate) metabolism (Rattus norvegicus)
CYB5A:heme reduces Asc.- to AscH- (Rattus norvegicus)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Rattus norvegicus)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
AscH- [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Carnitine synthesis (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ [cytosol] (Saccharomyces cerevisiae)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Vitamin C (ascorbate) metabolism (Saccharomyces cerevisiae)
CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)
AscH- [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Vitamin C (ascorbate) metabolism (Schizosaccharomyces pombe)
CYB5A:heme reduces Asc.- to AscH- (Schizosaccharomyces pombe)
AscH- [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)
FIH1:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
FIH1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Sus scrofa)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
VBC complex (with or without LIMD1) [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Sus scrofa)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Sus scrofa)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Sus scrofa)
PHD2,3 [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Carnitine synthesis (Sus scrofa)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
BBOX1:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Sus scrofa)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Sus scrofa)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Tyrosine catabolism (Sus scrofa)
HPD dioxygenates HPP (Sus scrofa)
HPD:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
HPD:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Sus scrofa)
HPD:AscH-:Fe2+ dimer [cytosol] (Sus scrofa)
HPD:AscH-:Fe2+ [cytosol] (Sus scrofa)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Vitamin C (ascorbate) metabolism (Sus scrofa)
CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Sus scrofa)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)
AscH- [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to hypoxia (Xenopus tropicalis)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)
FIH1:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
FIH1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Xenopus tropicalis)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
PHD2,3 [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Carnitine synthesis (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)
TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix] (Xenopus tropicalis)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Xenopus tropicalis)
AscH- [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Tyrosine catabolism (Xenopus tropicalis)
HPD dioxygenates HPP (Xenopus tropicalis)
HPD:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
nitisinone:HPD dimer [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ dimer [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
AscH- [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Vitamin C (ascorbate) metabolism (Xenopus tropicalis)
CYB5A:heme reduces Asc.- to AscH- (Xenopus tropicalis)
AscH- [cytosol]
GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)
AscH- [cytosol]
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
AscH- [cytosol]
External Reference Information
External Reference
L-ascorbate [ChEBI:38290]
Participates
as a component of
BBOX1:AscH-:Fe2+ [cytosol] (Gallus gallus)
BBOX1:AscH-:Fe2+ [cytosol] (Canis familiaris)
BBOX1:AscH-:Fe2+ [cytosol] (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ [cytosol] (Danio rerio)
BBOX1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
BBOX1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ [cytosol] (Sus scrofa)
BBOX1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
BBOX1:AscH-:Fe2+ [cytosol] (Mus musculus)
BBOX1:AscH-:Fe2+ [cytosol] (Bos taurus)
BBOX1:AscH-:Fe2+ [cytosol] (Homo sapiens)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Mus musculus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Sus scrofa)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Drosophila melanogaster)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Canis familiaris)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Caenorhabditis elegans)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Bos taurus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Xenopus tropicalis)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Rattus norvegicus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Gallus gallus)
TMLHE:AscH-:Fe2+ [mitochondrial matrix] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
HPD:AscH-:Fe2+ [cytosol] (Dictyostelium discoideum)
HPD:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
HPD:AscH-:Fe2+ [cytosol] (Bos taurus)
HPD:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
HPD:AscH-:Fe2+ [cytosol] (Mus musculus)
HPD:AscH-:Fe2+ [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
EGLN3:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
EGLN1:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN1:AscH-:Fe2+ [cytosol] (Canis familiaris)
EGLN1:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
EGLN1:AscH-:Fe2+ [cytosol] (Bos taurus)
EGLN1:AscH-:Fe2+ [cytosol] (Sus scrofa)
EGLN1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
EGLN1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
EGLN1:AscH-:Fe2+ [cytosol] (Mus musculus)
EGLN1:AscH-:Fe2+ [cytosol] (Gallus gallus)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
EGLN3:AscH-:Fe2+ [cytosol] (Drosophila melanogaster)
EGLN3:AscH-:Fe2+ [cytosol] (Canis familiaris)
EGLN3:AscH-:Fe2+ [cytosol] (Bos taurus)
EGLN3:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
EGLN3:AscH-:Fe2+ [cytosol] (Mus musculus)
EGLN3:AscH-:Fe2+ [cytosol] (Gallus gallus)
EGLN3:AscH-:Fe2+ [cytosol] (Sus scrofa)
FIH1:AscH-:Fe2+ [cytosol] (Homo sapiens)
FIH1:AscH-:Fe2+ [cytosol] (Bos taurus)
FIH1:AscH-:Fe2+ [cytosol] (Sus scrofa)
FIH1:AscH-:Fe2+ [cytosol] (Canis familiaris)
FIH1:AscH-:Fe2+ [cytosol] (Xenopus tropicalis)
FIH1:AscH-:Fe2+ [cytosol] (Mus musculus)
FIH1:AscH-:Fe2+ [cytosol] (Rattus norvegicus)
FIH1:AscH-:Fe2+ [cytosol] (Danio rerio)
FIH1:AscH-:Fe2+ [cytosol] (Gallus gallus)
HPD:AscH-:Fe2+ [cytosol] (Canis familiaris)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Danio rerio)
HPD:AscH-:Fe2+ [cytosol] (Caenorhabditis elegans)
HPD:AscH-:Fe2+ [cytosol] (Gallus gallus)
as an input of
Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)
as an output of
CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)
CYB5A:heme reduces Asc.- to AscH- (Schizosaccharomyces pombe)
CYB5A:heme reduces Asc.- to AscH- (Dictyostelium discoideum)
CYB5A:heme reduces Asc.- to AscH- (Caenorhabditis elegans)
CYB5A:heme reduces Asc.- to AscH- (Drosophila melanogaster)
CYB5A:heme reduces Asc.- to AscH- (Gallus gallus)
CYB5A:heme reduces Asc.- to AscH- (Xenopus tropicalis)
CYB5A:heme reduces Asc.- to AscH- (Danio rerio)
CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)
CYB5A:heme reduces Asc.- to AscH- (Bos taurus)
CYB5A:heme reduces Asc.- to AscH- (Canis familiaris)
CYB5A:heme reduces Asc.- to AscH- (Rattus norvegicus)
CYB5A:heme reduces Asc.- to AscH- (Mus musculus)
CYB5A:heme reduces Asc.- to AscH- (Homo sapiens)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Gallus gallus)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Canis familiaris)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)
SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Homo sapiens)
Asc.- radical dissociates to AscH- and DeHA (Homo sapiens)
GSTO dimers reduce DeHA to AscH- (Homo sapiens)
GSTO dimers reduce DeHA to AscH- (Mus musculus)
GSTO dimers reduce DeHA to AscH- (Rattus norvegicus)
GSTO dimers reduce DeHA to AscH- (Canis familiaris)
GSTO dimers reduce DeHA to AscH- (Bos taurus)
GSTO dimers reduce DeHA to AscH- (Sus scrofa)
GSTO dimers reduce DeHA to AscH- (Danio rerio)
GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)
GSTO dimers reduce DeHA to AscH- (Gallus gallus)
GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)
GSTO dimers reduce DeHA to AscH- (Caenorhabditis elegans)
Other forms of this molecule
AscH- [extracellular region]
AscH- [secretory granule lumen]
AscH- [nucleoplasm]
Cross References
AraCyc
ASCORBATE
CAS
50-81-7
COMPOUND
C00072
PubChem Compound
44229109
ZINC
000100006770
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![AscH- [cytosol] icon](/icon/R-ICO-013873.svg){kind=icon}
