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About
What is Reactome ?
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Team
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Digital Preservation
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Table of Contents
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Docs
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How do I search ?
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BH4 [cytosol]
Stable Identifier
R-ALL-29870
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin, 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of amine-derived hormones (Bos taurus)
Catecholamine biosynthesis (Bos taurus)
Tyrosine is hydroxylated to dopa (Bos taurus)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Bos taurus)
Tryptophan is hydroxylated (Bos taurus)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)
BH4 [cytosol]
Metabolism of lipids (Bos taurus)
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Bos taurus)
NOSIP mediated eNOS trafficking (Bos taurus)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)
eNOS:NOSIP [Golgi membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
BH4 [cytosol]
NOSTRIN mediated eNOS trafficking (Bos taurus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Bos taurus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
BH4 [cytosol]
eNOS activation (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Bos taurus)
myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Bos taurus)
BH4 [cytosol]
depalmitoylation of eNOS (Bos taurus)
myristoylated eNOS dimer [cytosol] (Bos taurus)
BH4 [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Bos taurus)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
Signal Transduction (Bos taurus)
Signaling by Nuclear Receptors (Bos taurus)
ESR-mediated signaling (Bos taurus)
Extra-nuclear estrogen signaling (Bos taurus)
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by VEGF (Bos taurus)
VEGFA-VEGFR2 Pathway (Bos taurus)
VEGFR2 mediated vascular permeability (Bos taurus)
AKT1 phosphorylates eNOS (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
eNOS synthesizes NO (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
BH4 [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Catecholamine biosynthesis (Caenorhabditis elegans)
Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Caenorhabditis elegans)
Tryptophan is hydroxylated (Caenorhabditis elegans)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)
BH4 [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Caenorhabditis elegans)
eNOS activation (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Nuclear Receptors (Caenorhabditis elegans)
ESR-mediated signaling (Caenorhabditis elegans)
Extra-nuclear estrogen signaling (Caenorhabditis elegans)
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by VEGF (Caenorhabditis elegans)
VEGFA-VEGFR2 Pathway (Caenorhabditis elegans)
VEGFR2 mediated vascular permeability (Caenorhabditis elegans)
AKT1 phosphorylates eNOS (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
eNOS synthesizes NO (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
BH4 [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of amine-derived hormones (Canis familiaris)
Catecholamine biosynthesis (Canis familiaris)
Tyrosine is hydroxylated to dopa (Canis familiaris)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Canis familiaris)
Tryptophan is hydroxylated (Canis familiaris)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)
BH4 [cytosol]
Metabolism of lipids (Canis familiaris)
Triglyceride metabolism (Canis familiaris)
Triglyceride biosynthesis (Canis familiaris)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
NOSTRIN mediated eNOS trafficking (Canis familiaris)
NOSTRIN mediated translocation of eNOS from plasma membrane (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Canis familiaris)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Canis familiaris)
GCH1 reduces GTP to dihydroneopterin triphosphate (Canis familiaris)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)
BH4 [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Metabolism of amine-derived hormones (Danio rerio)
Catecholamine biosynthesis (Danio rerio)
Tyrosine is hydroxylated to dopa (Danio rerio)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Danio rerio)
Tryptophan is hydroxylated (Danio rerio)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)
BH4 [cytosol]
Metabolism of lipids (Danio rerio)
Triglyceride metabolism (Danio rerio)
Triglyceride biosynthesis (Danio rerio)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Danio rerio)
NOSTRIN mediated eNOS trafficking (Danio rerio)
NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Danio rerio)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Danio rerio)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)
BH4 [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Catecholamine biosynthesis (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Dictyostelium discoideum)
Tryptophan is hydroxylated (Dictyostelium discoideum)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)
BH4 [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Triglyceride metabolism (Dictyostelium discoideum)
Triglyceride biosynthesis (Dictyostelium discoideum)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Dictyostelium discoideum)
NOSIP mediated eNOS trafficking (Dictyostelium discoideum)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Dictyostelium discoideum)
eNOS:NOSIP [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
BH4 [cytosol]
eNOS activation (Dictyostelium discoideum)
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
BH4 [cytosol]
depalmitoylation of eNOS (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
BH4 [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by VEGF (Dictyostelium discoideum)
VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
VEGFR2 mediated vascular permeability (Dictyostelium discoideum)
AKT1 phosphorylates eNOS (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
eNOS synthesizes NO (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
BH4 [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of amine-derived hormones (Drosophila melanogaster)
Catecholamine biosynthesis (Drosophila melanogaster)
Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Drosophila melanogaster)
Tryptophan is hydroxylated (Drosophila melanogaster)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
NOSIP mediated eNOS trafficking (Drosophila melanogaster)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Drosophila melanogaster)
eNOS:NOSIP [Golgi membrane] (Drosophila melanogaster)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
BH4 [cytosol]
eNOS activation (Drosophila melanogaster)
AKT1 phosphorylates eNOS (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)
myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
BH4 [cytosol]
depalmitoylation of eNOS (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
BH4 [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Drosophila melanogaster)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT1 phosphorylates eNOS (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
BH4 [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Metabolism of amine-derived hormones (Gallus gallus)
Catecholamine biosynthesis (Gallus gallus)
Tyrosine is hydroxylated to dopa (Gallus gallus)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Gallus gallus)
Tryptophan is hydroxylated (Gallus gallus)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Gallus gallus)
BH4 [cytosol]
Metabolism of lipids (Gallus gallus)
Triglyceride metabolism (Gallus gallus)
Triglyceride biosynthesis (Gallus gallus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Gallus gallus)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
NOSTRIN mediated eNOS trafficking (Gallus gallus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Gallus gallus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Gallus gallus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Gallus gallus)
BH4 [cytosol]
eNOS activation (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Gallus gallus)
myristoylated eNOS dimer [Golgi membrane] (Gallus gallus)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Gallus gallus)
BH4 [cytosol]
depalmitoylation of eNOS (Gallus gallus)
myristoylated eNOS dimer [cytosol] (Gallus gallus)
BH4 [cytosol]
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Gallus gallus)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Gallus gallus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
BH4 [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Phenylketonuria (Homo sapiens)
Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)
BH4 [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Catecholamine biosynthesis (Homo sapiens)
Tyrosine is hydroxylated to dopa (Homo sapiens)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Homo sapiens)
Tryptophan is hydroxylated (Homo sapiens)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)
BH4 [cytosol]
Metabolism of lipids (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride biosynthesis (Homo sapiens)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSIP mediated eNOS trafficking (Homo sapiens)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Homo sapiens)
eNOS:NOSIP [Golgi membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
BH4 [cytosol]
NOSTRIN mediated eNOS trafficking (Homo sapiens)
NOSTRIN mediated translocation of eNOS from plasma membrane (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Homo sapiens)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Homo sapiens)
BH4 [cytosol]
eNOS activation (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)
myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Homo sapiens)
BH4 [cytosol]
depalmitoylation of eNOS (Homo sapiens)
myristoylated eNOS dimer [cytosol] (Homo sapiens)
BH4 [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Homo sapiens)
Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)
BH4 [cytosol]
Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)
BH4 [cytosol]
Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)
BH4 [cytosol]
Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated vascular permeability (Homo sapiens)
AKT1 phosphorylates eNOS (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
eNOS synthesizes NO (Homo sapiens)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
BH4 [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Metabolism of amine-derived hormones (Mus musculus)
Catecholamine biosynthesis (Mus musculus)
Tyrosine is hydroxylated to dopa (Mus musculus)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Mus musculus)
Tryptophan is hydroxylated (Mus musculus)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Phenylalanine metabolism (Mus musculus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)
BH4 [cytosol]
Metabolism of lipids (Mus musculus)
Triglyceride metabolism (Mus musculus)
Triglyceride biosynthesis (Mus musculus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Mus musculus)
NOSIP mediated eNOS trafficking (Mus musculus)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)
eNOS:NOSIP [Golgi membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
BH4 [cytosol]
NOSTRIN mediated eNOS trafficking (Mus musculus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Mus musculus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Mus musculus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Mus musculus)
BH4 [cytosol]
eNOS activation (Mus musculus)
AKT1 phosphorylates eNOS (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Mus musculus)
myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Mus musculus)
BH4 [cytosol]
depalmitoylation of eNOS (Mus musculus)
myristoylated eNOS dimer [cytosol] (Mus musculus)
BH4 [cytosol]
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Mus musculus)
BH2 binding can lead to eNOS uncoupling (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
Signal Transduction (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by VEGF (Mus musculus)
VEGFA-VEGFR2 Pathway (Mus musculus)
VEGFR2 mediated vascular permeability (Mus musculus)
AKT1 phosphorylates eNOS (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
eNOS synthesizes NO (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
BH4 [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of nitric oxide: NOS3 activation and regulation (Plasmodium falciparum)
NOSIP mediated eNOS trafficking (Plasmodium falciparum)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)
eNOS:NOSIP [Golgi membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
BH4 [cytosol]
eNOS activation (Plasmodium falciparum)
AKT1 phosphorylates eNOS (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Plasmodium falciparum)
myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Plasmodium falciparum)
BH4 [cytosol]
eNOS synthesizes NO (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of cofactors (Plasmodium falciparum)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Plasmodium falciparum)
BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
Signal Transduction (Plasmodium falciparum)
Signaling by Nuclear Receptors (Plasmodium falciparum)
ESR-mediated signaling (Plasmodium falciparum)
Extra-nuclear estrogen signaling (Plasmodium falciparum)
eNOS synthesizes NO (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Plasmodium falciparum)
Signaling by VEGF (Plasmodium falciparum)
VEGFA-VEGFR2 Pathway (Plasmodium falciparum)
VEGFR2 mediated vascular permeability (Plasmodium falciparum)
AKT1 phosphorylates eNOS (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
eNOS synthesizes NO (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
BH4 [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Metabolism of amine-derived hormones (Rattus norvegicus)
Catecholamine biosynthesis (Rattus norvegicus)
Tyrosine is hydroxylated to dopa (Rattus norvegicus)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Rattus norvegicus)
Tryptophan is hydroxylated (Rattus norvegicus)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Phenylalanine metabolism (Rattus norvegicus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)
BH4 [cytosol]
Metabolism of lipids (Rattus norvegicus)
Triglyceride metabolism (Rattus norvegicus)
Triglyceride biosynthesis (Rattus norvegicus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
NOSIP mediated eNOS trafficking (Rattus norvegicus)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)
eNOS:NOSIP [Golgi membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
BH4 [cytosol]
NOSTRIN mediated eNOS trafficking (Rattus norvegicus)
NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Rattus norvegicus)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Rattus norvegicus)
BH4 [cytosol]
eNOS activation (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)
myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Rattus norvegicus)
BH4 [cytosol]
depalmitoylation of eNOS (Rattus norvegicus)
myristoylated eNOS dimer [cytosol] (Rattus norvegicus)
BH4 [cytosol]
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Rattus norvegicus)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
BH4 [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of nitric oxide: NOS3 activation and regulation (Saccharomyces cerevisiae)
eNOS activation (Saccharomyces cerevisiae)
AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)
myristoylated eNOS dimer [Golgi membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Saccharomyces cerevisiae)
BH4 [cytosol]
depalmitoylation of eNOS (Saccharomyces cerevisiae)
myristoylated eNOS dimer [cytosol] (Saccharomyces cerevisiae)
BH4 [cytosol]
eNOS synthesizes NO (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of cofactors (Saccharomyces cerevisiae)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Saccharomyces cerevisiae)
BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Saccharomyces cerevisiae)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
Signal Transduction (Saccharomyces cerevisiae)
Signaling by Nuclear Receptors (Saccharomyces cerevisiae)
ESR-mediated signaling (Saccharomyces cerevisiae)
Extra-nuclear estrogen signaling (Saccharomyces cerevisiae)
eNOS synthesizes NO (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
Signaling by VEGF (Saccharomyces cerevisiae)
VEGFA-VEGFR2 Pathway (Saccharomyces cerevisiae)
VEGFR2 mediated vascular permeability (Saccharomyces cerevisiae)
AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
eNOS synthesizes NO (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
BH4 [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of nitric oxide: NOS3 activation and regulation (Schizosaccharomyces pombe)
eNOS activation (Schizosaccharomyces pombe)
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Schizosaccharomyces pombe)
myristoylated eNOS dimer [Golgi membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Schizosaccharomyces pombe)
BH4 [cytosol]
depalmitoylation of eNOS (Schizosaccharomyces pombe)
myristoylated eNOS dimer [cytosol] (Schizosaccharomyces pombe)
BH4 [cytosol]
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
Signal Transduction (Schizosaccharomyces pombe)
Signaling by Nuclear Receptors (Schizosaccharomyces pombe)
ESR-mediated signaling (Schizosaccharomyces pombe)
Extra-nuclear estrogen signaling (Schizosaccharomyces pombe)
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Schizosaccharomyces pombe)
Signaling by VEGF (Schizosaccharomyces pombe)
VEGFA-VEGFR2 Pathway (Schizosaccharomyces pombe)
VEGFR2 mediated vascular permeability (Schizosaccharomyces pombe)
AKT1 phosphorylates eNOS (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
eNOS synthesizes NO (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
BH4 [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Metabolism of amine-derived hormones (Sus scrofa)
Catecholamine biosynthesis (Sus scrofa)
Tyrosine is hydroxylated to dopa (Sus scrofa)
BH4 [cytosol]
Serotonin and melatonin biosynthesis (Sus scrofa)
Tryptophan is hydroxylated (Sus scrofa)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Phenylalanine metabolism (Sus scrofa)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)
BH4 [cytosol]
Metabolism of lipids (Sus scrofa)
Triglyceride metabolism (Sus scrofa)
Triglyceride biosynthesis (Sus scrofa)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)
BH4 [cytosol]
Metabolism of nitric oxide: NOS3 activation and regulation (Sus scrofa)
NOSIP mediated eNOS trafficking (Sus scrofa)
eNOS:NOSIP translocation from caveolae to intracellular compartments (Sus scrofa)
eNOS:NOSIP [Golgi membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
BH4 [cytosol]
NOSTRIN mediated eNOS trafficking (Sus scrofa)
NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [endocytic vesicle membrane] (Sus scrofa)
eNOS:Caveolin-1 [endocytic vesicle membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Sus scrofa)
BH4 [cytosol]
eNOS activation (Sus scrofa)
AKT1 phosphorylates eNOS (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
Uncoupled eNOS favours the formation of superoxide (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)
myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
BH4 [cytosol]
myristoylated eNOS dimer [cytosol] (Sus scrofa)
BH4 [cytosol]
depalmitoylation of eNOS (Sus scrofa)
myristoylated eNOS dimer [cytosol] (Sus scrofa)
BH4 [cytosol]
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of cofactors (Sus scrofa)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Sus scrofa)
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Nuclear Receptors (Sus scrofa)
ESR-mediated signaling (Sus scrofa)
Extra-nuclear estrogen signaling (Sus scrofa)
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
VEGFR2 mediated vascular permeability (Sus scrofa)
AKT1 phosphorylates eNOS (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
BH4 [cytosol]
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
BH4 [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Metabolism of amine-derived hormones (Xenopus tropicalis)
Catecholamine biosynthesis (Xenopus tropicalis)
Tyrosine is hydroxylated to dopa (Xenopus tropicalis)
BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Phenylalanine metabolism (Xenopus tropicalis)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)
BH4 [cytosol]
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)
BH4 [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Triglyceride metabolism (Xenopus tropicalis)
Triglyceride biosynthesis (Xenopus tropicalis)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)
BH4 [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of cofactors (Xenopus tropicalis)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Xenopus tropicalis)
GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)
BH4 [cytosol]
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)
BH4 [cytosol]
External Reference Information
External Reference
5,6,7,8-tetrahydrobiopterin [ChEBI:15372]
Participates
as a component of
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Danio rerio)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Canis familiaris)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Gallus gallus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [endocytic vesicle membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
palmitoylated, myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Bos taurus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Mus musculus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Gallus gallus)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Drosophila melanogaster)
myristoylated eNOS dimer [Golgi membrane] (Drosophila melanogaster)
myristoylated eNOS dimer [cytosol] (Homo sapiens)
myristoylated eNOS dimer [cytosol] (Dictyostelium discoideum)
myristoylated eNOS dimer [cytosol] (Rattus norvegicus)
myristoylated eNOS dimer [cytosol] (Saccharomyces cerevisiae)
myristoylated eNOS dimer [cytosol] (Mus musculus)
myristoylated eNOS dimer [cytosol] (Plasmodium falciparum)
myristoylated eNOS dimer [cytosol] (Bos taurus)
myristoylated eNOS dimer [cytosol] (Sus scrofa)
myristoylated eNOS dimer [cytosol] (Gallus gallus)
myristoylated eNOS dimer [cytosol] (Schizosaccharomyces pombe)
myristoylated eNOS dimer [Golgi membrane] (Homo sapiens)
myristoylated eNOS dimer [Golgi membrane] (Saccharomyces cerevisiae)
myristoylated eNOS dimer [Golgi membrane] (Mus musculus)
myristoylated eNOS dimer [Golgi membrane] (Gallus gallus)
myristoylated eNOS dimer [Golgi membrane] (Plasmodium falciparum)
myristoylated eNOS dimer [Golgi membrane] (Rattus norvegicus)
myristoylated eNOS dimer [Golgi membrane] (Sus scrofa)
myristoylated eNOS dimer [Golgi membrane] (Schizosaccharomyces pombe)
myristoylated eNOS dimer [Golgi membrane] (Dictyostelium discoideum)
myristoylated eNOS dimer [Golgi membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Homo sapiens)
p-S1177-eNOS dimer [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS dimer [plasma membrane] (Dictyostelium discoideum)
p-S1177-eNOS dimer [plasma membrane] (Saccharomyces cerevisiae)
p-S1177-eNOS dimer [plasma membrane] (Mus musculus)
p-S1177-eNOS dimer [plasma membrane] (Bos taurus)
p-S1177-eNOS dimer [plasma membrane] (Plasmodium falciparum)
p-S1177-eNOS dimer [plasma membrane] (Schizosaccharomyces pombe)
p-S1177-eNOS dimer [plasma membrane] (Caenorhabditis elegans)
p-S1177-eNOS dimer [plasma membrane] (Sus scrofa)
as an input of
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Caenorhabditis elegans)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Gallus gallus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Xenopus tropicalis)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)
AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)
Defective PAH does not hydroxylate L-Phe to L-Tyr (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
Tyrosine is hydroxylated to dopa (Gallus gallus)
Tyrosine is hydroxylated to dopa (Xenopus tropicalis)
Tyrosine is hydroxylated to dopa (Danio rerio)
Tyrosine is hydroxylated to dopa (Sus scrofa)
Tyrosine is hydroxylated to dopa (Bos taurus)
Tyrosine is hydroxylated to dopa (Canis familiaris)
Tyrosine is hydroxylated to dopa (Rattus norvegicus)
Tyrosine is hydroxylated to dopa (Mus musculus)
Tyrosine is hydroxylated to dopa (Homo sapiens)
Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)
BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Plasmodium falciparum)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Schizosaccharomyces pombe)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Bos taurus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)
Tryptophan is hydroxylated (Homo sapiens)
Tryptophan is hydroxylated (Mus musculus)
Tryptophan is hydroxylated (Rattus norvegicus)
Tryptophan is hydroxylated (Canis familiaris)
Tryptophan is hydroxylated (Bos taurus)
Tryptophan is hydroxylated (Sus scrofa)
Tryptophan is hydroxylated (Danio rerio)
Tryptophan is hydroxylated (Gallus gallus)
Tryptophan is hydroxylated (Drosophila melanogaster)
Tryptophan is hydroxylated (Caenorhabditis elegans)
Tryptophan is hydroxylated (Dictyostelium discoideum)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
as an output of
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Dictyostelium discoideum)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Gallus gallus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Xenopus tropicalis)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Sus scrofa)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Rattus norvegicus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Mus musculus)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)
q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)
Salvage - BH2 is reduced to BH4 by Dhfr (Mus musculus)
Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)
BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
BH2 binding can lead to eNOS uncoupling (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Mus musculus)
Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Gallus gallus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Danio rerio)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Sus scrofa)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Mus musculus)
Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)
PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Homo sapiens)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
This entity regulates
Negatively
GCH1 reduces GTP to dihydroneopterin triphosphate
(Saccharomyces cerevisiae)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Schizosaccharomyces pombe)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Dictyostelium discoideum)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Caenorhabditis elegans)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Drosophila melanogaster)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Gallus gallus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Xenopus tropicalis)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Sus scrofa)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Bos taurus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Canis familiaris)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Rattus norvegicus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Mus musculus)
GCH1 reduces GTP to dihydroneopterin triphosphate
(Homo sapiens)
Cross References
COMPOUND
C00272
PubChem Substance
8143160
HMDB Metabolite
HMDB0257929
ZINC
000018059633
,
000004228257
,
000013585233
,
000000895154
,
000002539827
,
000004228258
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