2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O

Stable Identifier
R-GGA-421452
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PPOX dimer in the mitochondrial intermembrane space catalyzes the reaction of two molecules of protoporphyrinogen IX and three of oxygen to form two molecules of protoporphyrin IX and sx of water. While the process of heme biosynthesis, including this reaction, is believed to be well conserved among vertebrates, no chicken gene capable of encoding a PPOX homologue has yet been discovered, and this reaction and all of the properties of chicken PPOX enzyme are inferred from those of their better-studied human counterparts.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

oxygen-dependent protoporphyrinogen oxidase activity of PPOX dimer [mitochondrial intermembrane space]

Physical Entity
PPOX dimer [mitochondrial intermembrane space] (Gallus gallus)
Activity
oxygen-dependent protoporphyrinogen oxidase activity (GO:0004729)
Inferred From
PPO oxidises PPGEN9 to PRIN9 (Homo sapiens)
Authored
D'Eustachio, P  (2009-05-19)
Created
D'Eustachio, P  (2009-05-19)
Cite Us!