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Effects of PIP2 hydrolysis
Stable Identifier
R-HSA-114508
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
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Hydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into the cytosol, but as DAG is a hydrophobic lipid it remains within the plasma membrane. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, while DAG activates the conventional and unconventional protein kinase C (PKC) isoforms, facilitating the translocation of PKC from the cytosol to the plasma membrane. The effects of DAG are mimicked by tumor-promoting phorbol esters. DAG is also a precursor for the biosynthesis of prostaglandins, the endocannabinoid 2-arachidonoylglycerol and an activator of a subfamily of TRP-C (Transient Receptor Potential Canonical) cation channels 3, 6, and 7.
Literature References
PubMed ID
Title
Journal
Year
9601053
The extended protein kinase C superfamily
Mellor, H
,
Parker, PJ
Biochem J
1998
17157506
Diacylglycerol, when simplicity becomes complex
Carrasco, S
,
Mérida, I
Trends Biochem Sci
2007
Participants
Events
Binding of IP3 to IP3 receptor
(Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol
(Homo sapiens)
Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs)
(Homo sapiens)
Activation of Protein Kinase C novel isoforms
(Homo sapiens)
DAG activation of TRPC channels
(Homo sapiens)
Arachidonate production from DAG
(Homo sapiens)
DAG kinase produces phosphatidic acid from DAG
(Homo sapiens)
Participates
as an event of
Platelet activation, signaling and aggregation (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Orthologous Events
Effects of PIP2 hydrolysis (Bos taurus)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Canis familiaris)
Effects of PIP2 hydrolysis (Danio rerio)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Gallus gallus)
Effects of PIP2 hydrolysis (Mus musculus)
Effects of PIP2 hydrolysis (Plasmodium falciparum)
Effects of PIP2 hydrolysis (Rattus norvegicus)
Effects of PIP2 hydrolysis (Saccharomyces cerevisiae)
Effects of PIP2 hydrolysis (Schizosaccharomyces pombe)
Effects of PIP2 hydrolysis (Sus scrofa)
Effects of PIP2 hydrolysis (Xenopus tropicalis)
Created
Farndale, R (2004-09-25)
Pace, NP (2004-09-25)
de Bono, B (2004-09-25)
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