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Early Phase of HIV Life Cycle
Stable Identifier
R-HSA-162594
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
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In the
early phase
of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. HIV RNA genome is reverse transcribed by the viral Reverse Transcriptase to form a cDNA copy, that gets inserted into host cell DNA. The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. The host DNA repair enzymes probably repair the breaks in DNA at the sites of integration.
Literature References
PubMed ID
Title
Journal
Year
12091904
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
Peterlin, BM
,
Greene, WC
Nat Med
2002
Participants
Events
Binding and entry of HIV virion
(Homo sapiens)
Uncoating of the HIV Virion
(Homo sapiens)
Formation of RTC (Reverse Transcription Complex)
(Homo sapiens)
Annealing of 3'-end of unwound transfer RNA primer with genomic RNA
(Homo sapiens)
Reverse Transcription of HIV RNA
(Homo sapiens)
Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
(Homo sapiens)
Integration of provirus
(Homo sapiens)
Participates
as an event of
HIV Life Cycle (Homo sapiens)
Event Information
Go Biological Process
viral process (0016032)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Gopinathrao, G (2006-05-16)
Iordanskiy, S (2006-05-16)
Bukrinsky, M (2006-05-16)
Morrow, MP (2006-05-16)
D'Eustachio, P (2006-05-16)
Reviewed
Hughes, SH (2006-10-31)
Bushman, FD (2006-10-31)
Reeves, J (2006-10-31)
Aiken, C (2006-10-31)
Created
Joshi-Tope, G (2005-04-01)
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