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Synthesis and processing of ENV and VPU
Stable Identifier
R-HSA-171286
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Assembly Of The HIV Virion (Homo sapiens)
Synthesis and processing of ENV and VPU (Homo sapiens)
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The two viral membrane proteins, Env and the accessory protein Vpu, which are encoded by the same mRNA, are translated on the rough ER. All virion components need to traffic from their point of synthesis to sites of assembly on the plasma membrane. Env is an integral membrane protein. It is inserted cotranslationally into ER membranes and then travels through the cellular secretory pathway where it is glycosylated, assembled into trimeric complexes, processed into the gp41 and gp120 subunits by the cellular protease furin.
Literature References
PubMed ID
Title
Journal
Year
22762019
HIV-1 Assembly, Budding, and Maturation
Sundquist, WI
,
Kräusslich, HG
Cold Spring Harb Perspect Med
2012
Participants
Events
Splicing of HIV RNA transcript
(Homo sapiens)
Synthesis of ENV polyprotein
(Homo sapiens)
Glycosylation of ENV polyprotein
(Homo sapiens)
Folding and Oligomerization of ENV glycoprotein
(Homo sapiens)
Transport of trimeric ENV precursor to Golgi apparatus
(Homo sapiens)
Cleavage of the viral Env gp160 precursor polyprotein
(Homo sapiens)
Transport of trimeric gp41:gp120 to plasma membrane
(Homo sapiens)
Synthesis of VPU protein
(Homo sapiens)
Transport of VPU to Golgi apparatus
(Homo sapiens)
Transport of VPU to Plasma Membrane
(Homo sapiens)
Participates
as an event of
Assembly Of The HIV Virion (Homo sapiens)
Event Information
Go Biological Process
viral protein processing (0019082)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Gillespie, ME (2013-03-07)
Reviewed
Dube, M (2013-05-21)
Created
Gopinathrao, G (2006-02-03)
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