UDP-glucose is oxidised to UDP-glucuronate

Stable Identifier
R-HSA-173597
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.
Literature References
PubMed ID Title Journal Year
15044486 Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations

Barycki, JJ, Simpson, MA, Sommer, BJ

J Biol Chem 2004
Participants
Participates
Catalyst Activity

UDP-glucose 6-dehydrogenase activity of 6xUGDH [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!