FDPS dimer transfers IPPP to GPP

Stable Identifier
R-HSA-191303
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
ReviewStatus
5/5
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Further condensation of an isopentenyl pyrophosphate (IPPP) with geranyl pyrophosphate (GPP) to form farnesyl pyrophosphate (FAPP) is catalyzed by the prenyltransferases FPP synthase and GGPP synthase (Kavanagh et al, 2006).
Literature References
PubMed ID Title Journal Year
9741684 Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression

Edwards, PA, Shell, BK, Greene, JM, Ericsson, J, Florence, C, Carter, KC, Duan, DR

J Lipid Res 1998
16684881 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

Knapp, S, Russell, RG, Guo, K, Oppermann, U, Ebetino, FH, Kavanagh, KL, Dunford, JE, Rogers, MJ, Wu, X

Proc Natl Acad Sci U S A 2006
10026212 Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.

Sagami, I, Kuzuguchi, T, Morita, Y, Sagami, H, Ogura, K

J Biol Chem 1999
Participants
Participates
Catalyst Activity

geranyltranstransferase activity of holo-FDPS dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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