GRB2 events in ERBB2 signaling

Stable Identifier
R-HSA-1963640
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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GRB2 events in ERBB2 signaling
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ERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. 1995, Sepp-Lorenzino et al. 1996), which, again, results in SOS1-mediated guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinases (Janes et al. 1994, Sepp-Lorenzino et al. 1996).
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Events
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Orthologous Events
GRB2 events in ERBB2 signaling (Bos taurus)
GRB2 events in ERBB2 signaling (Caenorhabditis elegans)
GRB2 events in ERBB2 signaling (Canis familiaris)
GRB2 events in ERBB2 signaling (Danio rerio)
GRB2 events in ERBB2 signaling (Drosophila melanogaster)
GRB2 events in ERBB2 signaling (Gallus gallus)
GRB2 events in ERBB2 signaling (Mus musculus)
GRB2 events in ERBB2 signaling (Rattus norvegicus)
GRB2 events in ERBB2 signaling (Sus scrofa)
GRB2 events in ERBB2 signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-11-04)
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