COASY transfers an adenylyl group from ATP to PPANT

Stable Identifier
R-HSA-196754
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
(R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate, Adenylation of phosphopantetheine
ReviewStatus
5/5
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The adenylyl transferase activity of bifunctional coenzyme A synthase (COASY) catalyzes the transfer of an adenylyl group from ATP to pantetheinephosphate (PPANT) to form dephospho-Coenzyme A (DP-CoA) (Daugherty et al. 2002). The enzyme is associated with the mitochondrial outer membrane (Zhyvoloup et al. 2003).
Literature References
PubMed ID Title Journal Year
14514684 Subcellular localization and regulation of coenzyme A synthase

Panasyuk, G, Kyyamova, R, Lyzogubov, V, Zhyvoloup, A, Filonenko, V, Valovka, T, Nemazanyy, I, Gorbenko, O, Wang, ML, Fenton, T, Foxon, R, Gout, IT, Matsuka, G, Rebholz, H, Usenko, V

J Biol Chem 2003
11994049 Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)

Worrall, DM, Aghajanian, S

Biochem J 2002
Participants
Participates
Catalyst Activity

pantetheine-phosphate adenylyltransferase activity of COASY [mitochondrial outer membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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