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Collagen type XVII [plasma membrane]
Stable Identifier
R-HSA-2152283
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Hemidesmosome formation (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Collagen type XVII fibril [plasma membrane] (Homo sapiens)
Collagen type XVII [plasma membrane] (Homo sapiens)
Type I hemidesmosome complex [extracellular region] (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Collagen type XVII fibril [plasma membrane] (Homo sapiens)
Collagen type XVII [plasma membrane] (Homo sapiens)
Collagen biosynthesis and modifying enzymes (Homo sapiens)
Secretion of transmembrane collagens (Homo sapiens)
Transmembrane collagens [plasma membrane] (Homo sapiens)
Collagen type XVII [plasma membrane] (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type XVII ectodomain shedding (Homo sapiens)
Collagen type XVII [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
LAIR1 binds collagen (Homo sapiens)
Collagen type XVII fibril [plasma membrane] (Homo sapiens)
Collagen type XVII [plasma membrane] (Homo sapiens)
LAIR1:Collagen type XVII [plasma membrane] (Homo sapiens)
Collagen type XVII fibril [plasma membrane] (Homo sapiens)
Collagen type XVII [plasma membrane] (Homo sapiens)
General
Collagen XVII is a transmembrane protein. It is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Two homotrimeric forms exist; a full length transmembrane form and a soluble form, referred to as either ectodomain or LAD-1, which is generated by proteolytic processing of the full length form by TACE (TNF-Alpha Converting Enzyme), a metalloproteinase of the ADAM family (fRANZKE ET AL. 2004). Each alpha-chain has an intracellular domain which interacts with beta4-integrin (Hopkinson et al. 1998), plectin and dystonin (BP230) and is necessary for the stable attachment of hemidesmosomes to keratin intermediate filaments (Hopkinson & Jones 2000).
Participants
components
x 3
Collagen alpha-1(XVII) chains [plasma membrane]
(Homo sapiens)
Participates
as a member of
Transmembrane collagens [plasma membrane] (Homo sapiens)
as a repeated unit of
Collagen type XVII fibril [plasma membrane] (Homo sapiens)
as an input of
Collagen type XVII ectodomain shedding (Homo sapiens)
Collagen type XVII ectodomain shedding (Homo sapiens)
Inferred To
Collagen type XVII [plasma membrane]
(Bos taurus)
Collagen type XVII [plasma membrane]
(Canis familiaris)
Collagen type XVII [plasma membrane]
(Gallus gallus)
Collagen type XVII [plasma membrane]
(Mus musculus)
Collagen type XVII [plasma membrane]
(Rattus norvegicus)
Collagen type XVII [plasma membrane]
(Sus scrofa)
Collagen type XVII [plasma membrane]
(Xenopus tropicalis)
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