Reactome | TTYH2/3 transport cytosolic Cl- to extracellular region

TTYH2/3 transport cytosolic Cl- to extracellular region

Stable Identifier

R-HSA-2744242

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

TTYH2/3 transport cytosolic Cl- to extracellular region

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human homologues 2 and 3 (TTYH2 and 3) mediate the efflux of Cl- from cells in response to the increase in intracellular Ca2+ levels (Suzuki & Mizuno 2004, Suzuki 2006). All CLCAs contain a consensus cleavage motif which is recognised by an internal zincin metalloprotease domain within the N terminus. Self-proteolysis within the secretory pathway yields N- and C-terminal fragments, a step critical for CLCA activation of calcium-activated chloride channels (CaCCs) mediated through the N-terminal fragment (Yurtsever et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
15010458	A novel human Cl(-) channel family related to Drosophila flightless locus Mizuno, A, Suzuki, M	J. Biol. Chem.	2004
16219661	The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels Suzuki, M	Exp. Physiol.	2006